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Spravato (Esketamine) Nasal Spray Clinics

The FDA-approved esketamine nasal spray for treatment-resistant depression, administered in certified clinics and often covered by insurance. 270 listed clinics offer this treatment across 42 states.

How Spravato (Esketamine) Nasal Spray Works

Spravato is the brand name for esketamine, an FDA-approved nasal spray for treatment-resistant depression and for depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions. Because it carries risks of sedation and dissociation, it can only be administered in healthcare settings certified under the FDA's REMS safety program — patients self-administer the spray in the office and are monitored for two hours.

Because Spravato is FDA-approved, it is the ketamine-class treatment most often covered by commercial insurance and Medicare, usually alongside an oral antidepressant. Treatment starts twice weekly for a month, then steps down to weekly or every-other-week maintenance. Clinics in this directory that appear in the official Spravato REMS locator as actively treating centers display a certification badge on their listing.

What to Expect at Your Appointment

Each visit: a pre-dose blood-pressure check, self-administering the nasal spray under supervision, then a mandatory two-hour monitored rest period before discharge with a driver. Most patients describe lighter dissociative effects than IV ketamine.

Spravato (Esketamine) Nasal Spray in Alabama

Spravato (Esketamine) Nasal Spray in Arizona

Renew Wellness

3303 E Baseline Rd, Suite 204, Gilbert, AZ 85234

Kamee Witts, PMHNP

4.8 (166 Google reviews)

  • Ketamine-Assisted Psychotherapy (KAP)
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in California

Seaside Ketamine

1953 San Elijo Ave #200, Cardiff, CA 92007

5.0 (1 Google reviews)

  • IV Ketamine Infusion
  • IM Ketamine Injection
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

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ZenKetamine

6538 Lonetree Blvd. Ste. 100, Rocklin, CA 95765

Erwin Victor Boco, MD

4.9 (33 Google reviews)

  • IV Ketamine Infusion
  • IM Ketamine Injection
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in Colorado

MindMorph LLC

1500 N Grant St., Ste R, Denver, CO 80203

5.0 (1 Google reviews)

  • Ketamine-Assisted Psychotherapy (KAP)
  • Oral Ketamine / Troches
  • Spravato (Esketamine) Nasal Spray

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Uchealth

1760 E Ken Pratt Blvd, Suite 305, Longmont, CO 80504

Jeanine Snyder, NP

3.7 (6 Google reviews)

  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in Connecticut

Spravato (Esketamine) Nasal Spray in Delaware

Initia Nova Delaware

3512 Silverside Rd, Suite 13, Wilmington, DE 19810

John Dougherty

5.0 (3 Google reviews)

  • IV Ketamine Infusion
  • Ketamine-Assisted Psychotherapy (KAP)
  • Spravato (Esketamine) Nasal Spray

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Therapeutic Infusions

1301 N Harrison St., Ste. 102, Wilmington, DE 19806

Joseph Raziano, MD

5.0 (30 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

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Spravato (Esketamine) Nasal Spray in District of Columbia

Spravato (Esketamine) Nasal Spray in Florida

Ketamine Lounge

400 W 41st St Ste 402, Miami Beach, FL 33140

5.0 (17 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

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Spravato (Esketamine) Nasal Spray in Georgia

Spravato (Esketamine) Nasal Spray in Idaho

Boise Ketamine Clinic

2800 W Overland Road, Boise, ID 83705

Nykol Bailey Rice, CRNA, PMHNP

4.8 (44 Google reviews)

  • IV Ketamine Infusion
  • Ketamine-Assisted Psychotherapy (KAP)
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in Illinois

Spravato (Esketamine) Nasal Spray in Indiana

Spravato (Esketamine) Nasal Spray in Iowa

Spravato (Esketamine) Nasal Spray in Kansas

Spravato (Esketamine) Nasal Spray in Kentucky

Spravato (Esketamine) Nasal Spray in Louisiana

Spravato (Esketamine) Nasal Spray in Maryland

Spravato (Esketamine) Nasal Spray in Massachusetts

Emerge Ketamine

100 Trade Center, Suite G-700, Office 818, Woburn, MA 01801

4.8 (84 Google reviews)

  • IV Ketamine Infusion
  • IM Ketamine Injection
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in Michigan

Spravato (Esketamine) Nasal Spray in Minnesota

Spravato (Esketamine) Nasal Spray in Mississippi

Haven Health

129 Fountains Boulevard, Suite 101, Madison, MS 39110

L. Kevin Vance, MD

3.6 (40 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in Montana

Spravato (Esketamine) Nasal Spray in Nebraska

Spravato (Esketamine) Nasal Spray in Nevada

Spravato (Esketamine) Nasal Spray in New Hampshire

Spravato (Esketamine) Nasal Spray in New Jersey

KetaRevive

541 Cedar Hill Ave, 2nd floor, Wyckoff, NJ 07481

Joseph Affortunato, DO

4.8 (10 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in New York

PMC

PMC Psychedelic Medicine Centers of America, 25 South Regent St., Port Chester, NY 10573

Carlos Rueda, MD

5.0 (54 Google reviews)

  • IV Ketamine Infusion
  • IM Ketamine Injection
  • Oral Ketamine / Troches
  • Spravato (Esketamine) Nasal Spray

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Veda House, LLC

46 Lake Ave, Saratoga Springs, NY 12866

Amanda Bernard, NP

3.9 (7 Google reviews)

  • Ketamine-Assisted Psychotherapy (KAP)
  • Spravato (Esketamine) Nasal Spray

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Spravato (Esketamine) Nasal Spray in North Carolina

Spravato (Esketamine) Nasal Spray in Ohio

New Pathways Clinic

7275 Sawmill Rd., Dublin, OH 43016

Ashley Stepp, PMHNP

5.0 (26 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

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Spravato (Esketamine) Nasal Spray in Oklahoma

Spravato (Esketamine) Nasal Spray in Oregon

Spravato (Esketamine) Nasal Spray in Pennsylvania

Voyage Healing PC

191 Presidential Blvd, LN -24, Bala Cynwyd, PA 19004

Gail Serruya, MD

4.8 (45 Google reviews)

  • IV Ketamine Infusion
  • IM Ketamine Injection
  • Oral Ketamine / Troches
  • Spravato (Esketamine) Nasal Spray
  • +1 more

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Spravato (Esketamine) Nasal Spray in Rhode Island

Spravato (Esketamine) Nasal Spray in South Carolina

Spravato (Esketamine) Nasal Spray in South Dakota

Spravato (Esketamine) Nasal Spray in Tennessee

Spravato (Esketamine) Nasal Spray in Texas

CARMAhealth

630 W 34th St, Suite 301, Austin, TX 78705

Carlos Tirado, MD

3.0 (93 Google reviews)

  • Spravato (Esketamine) Nasal Spray
  • IV Ketamine Infusion

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Nura Therapy

4622 Saint Amand Cir, Fort Worth, TX 76126

Suhail Khan, MD

4.9 (37 Google reviews)

  • IV Ketamine Infusion
  • Ketamine-Assisted Psychotherapy (KAP)
  • Spravato (Esketamine) Nasal Spray

View clinic details →

Vigeo Wellness

906 West Cannon Street, Suite 100, Fort Worth, TX 76104

Paul Schneider, DO

5.0 (67 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

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Catalyst Ketamine

7710 Beechnut, Suite 206, Houston, TX 77074

Michael Ho, MD

4.9 (45 Google reviews)

  • IV Ketamine Infusion
  • Spravato (Esketamine) Nasal Spray
  • Ketamine-Assisted Psychotherapy (KAP)

View clinic details →

Spravato (Esketamine) Nasal Spray in Utah

Spravato (Esketamine) Nasal Spray in Virginia

Spravato (Esketamine) Nasal Spray in Washington

Spravato (Esketamine) Nasal Spray in Wisconsin

Spravato (Esketamine) Nasal Spray in Wyoming

Spravato (Esketamine) Nasal Spray — Frequently Asked Questions

What's the difference between Spravato and IV ketamine?

Spravato is FDA-approved esketamine (one mirror-half of the ketamine molecule) given as a nasal spray with insurance coverage and a required two-hour monitoring window. IV ketamine uses generic ketamine off-label, is usually cash-pay, and allows finer dose control.

Do I qualify for Spravato?

It's indicated for adults with treatment-resistant depression (typically two or more failed antidepressant trials) or MDD with acute suicidal thinking, prescribed alongside an oral antidepressant. A psychiatric evaluation at a REMS-certified center determines eligibility.

What does the REMS certification badge on listings mean?

It means the clinic appears in Janssen's official Spravato treatment-center locator as an actively treating outpatient center — an FDA-program-backed signal that the clinic is certified to administer esketamine.

Is Spravato covered by insurance?

Most commercial plans and Medicare cover Spravato for its approved indications, subject to prior authorization. Confirm coverage with the clinic and your insurer before starting.

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