How Much Does Ketamine Therapy Cost in 2026?

Ketamine therapy is usually paid out of pocket, and prices vary widely between clinics and delivery methods. Here's what patients typically pay in 2026, based on prices clinics publish publicly.

Typical Ketamine Pricing by Treatment Type

• IV ketamine infusion: roughly $350–$800 per session for mood disorders. Most clinics recommend an initial series of 6 infusions over 2–3 weeks, so a full induction commonly runs $2,100–$4,800. Chronic-pain infusions are longer and often cost more per session.
• IM (intramuscular) injection: usually somewhat less than IV at the same clinic, commonly $200–$500 per session.
• Spravato (esketamine) nasal spray: how much does Spravato cost? The drug itself is FDA-approved and frequently covered by commercial insurance and Medicare, so many patients pay a specialist copay per visit rather than the full cost, and Spravato's cost and savings programs can lower that further for eligible patients. Without coverage, sessions can exceed $600–$900 including observation time.
• Oral ketamine / troches: the least expensive form — at-home telehealth programs commonly run $100–$400 per month including prescriber oversight.
• Ketamine-assisted psychotherapy (KAP): priced like therapy plus medicine sessions; expect $250–$800 per dosing session depending on session length and therapist involvement.

Does Insurance Cover Ketamine Therapy?

Spravato is the exception:because it's FDA-approved for treatment-resistant depression, most insurance plans cover it (with prior authorization). Generic IV/IM/oral ketamine for mental health is prescribed off-label, so insurers rarely cover the treatment itself, though many clinics provide superbills for partial out-of-network reimbursement. For Medicare, Medicaid, TRICARE, VA, and HSA/FSA specifics, plus how to appeal a denied claim, see the full insurance coverage guide.

How to Keep Ketamine Treatment Costs Down

• Ask about package pricing — most clinics discount the 6-infusion induction series.
• If you have insurance, ask whether you're a candidate for Spravato first.
• Ask for a superbill and check your out-of-network benefits.
• Many clinics offer financing (CareCredit, Advance Care) or income-based sliding scales.
• Compare clinics near you — prices for the same treatment can differ by hundreds of dollars in the same city.

Every listing on this site shows pricing when the clinic publishes it. Browse clinics by state or see clinics offering Spravato if insurance coverage matters most to you.

Prices reflect publicly listed clinic rates as of mid-2026 and vary by market. This is general information, not medical or financial advice.